Influence of suxamethonium on the potency of ORG NC 45 in anaesthetized patients.
نویسندگان
چکیده
The non-depolarizing neuromuscular block produced by Org NC 45 was potentiated by the previous administration of suxamethonium 1 mg kg-1, shown by twitch depression of 91.3 +/- 2.4% when the same dose of Org NC 45 was administered after recovery from suxamethonium compared with the control value of 71.9 +/- 6.5%. The recovery index was also prolonged from 8.1 +/- 0.3 to 10.4 +/- 1.0 min after suxamethonium. The dose-response curves for Org NC 45 showed a 1.66 potentiation factor for ED50 and 1.73 for ED95, caused by the previous administration of suxamethonium. This interaction is likely to occur in the plasma.
منابع مشابه
Relative potency of ORG NC 45, pancuronium, alcuronium and tubocurarine in anaesthetized man.
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ورودعنوان ژورنال:
- British journal of anaesthesia
دوره 53 3 شماره
صفحات -
تاریخ انتشار 1981